You look like you could use a good laugh. Lucky for you, Wise Guys Comedy Showroom presents the very best in live, nationally known comedy entertainment. The comedy styles are always changing, but the laughs are the same, night after night. Wise Guys - Central New York's premier all-comedy-nightclub - is conveniently located on North Franklin St. near the heart of downtown Syracuse. Grab your friends and get to Wise Guy...this place is seriously funny.